منابع مشابه
Lysosomes
I have followed the lysosome field since it was proposed as a concept by deDuve and his co-workers in 1955 and find this collection of papers by workers in that field an interesting addition that has many sparkling con-addition, of course, to deDuve, to name a few) but it also has several several shortcomings. For the uninitiated (and there are surprisingly many for whom "lysosome" is a new wor...
متن کاملLysosomes
Figure 1. Lysosome fusion. Lysosomes fuse with late endosomes to form endolysosomes, which are major sites of acid hydrolase activity and the digestion of endocytosed cargo. Equivalent fusions of lysosomes with phagosomes or autophagosomes can also occur (not shown in detail). Lysosomes can be reformed from endolysosomes and autolysosomes via poorly understood fi ssion and maturation processes....
متن کاملThe pathway and targeting signal for delivery of the integral membrane glycoprotein LEP100 to lysosomes
A complete set of chimeras was made between the lysosomal membrane glycoprotein LEP100 and the plasma membrane-directed vesicular stomatitis virus G protein, combining a glycosylated lumenal or ectodomain, a single transmembrane domain, and a cytosolic carboxyl-terminal domain. These chimeras, the parent molecules, and a truncated form of LEP100 lacking the transmembrane and cytosolic domains w...
متن کاملThe proteome of lysosomes.
Lysosomes are organelles of eukaryotic cells that are critically involved in the degradation of macromolecules mainly delivered by endocytosis and autophagocytosis. Degradation is achieved by more than 60 hydrolases sequestered by a single phospholipid bilayer. The lysosomal membrane facilitates interaction and fusion with other compartments and harbours transport proteins catalysing the export...
متن کاملThe Gulf oil spill.
From the Department of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, Pittsburgh (B.D.G.); and the Department of Psychiatry, Louisiana State University Health Sciences Center (H.J.O.); and the Department of Environmental Health Sciences, Tulane University School of Public Health and Tropical Medicine (M.Y.L.) — both in New Orleans. Address repr...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2008
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri2393